3-Pyridinol, 2-methyl-

Name	3-Pyridinol, 2-methyl-
Synonyms	6-Methylpyridin-5-ol 2-METHYL-3-PYRIDINOL 3-HYDROXY-2-PICOLINE 2-methylpyridin-3-ol 3-Pyridinol, 2-methyl- 3-Hydroxy-2-methylpyridine 2-Methyl-3-hydroxypyridine 3-HYDROXY-2-METHYLPYRIDINE
CAS	1121-25-1
EINECS	214-327-3
InChI	InChI=1/C6H7NO/c1-5-6(8)3-2-4-7-5/h2-4,8H,1H3
InChIKey	AQSRRZGQRFFFGS-UHFFFAOYSA-N

Molecular Formula	C6H7NO
Molar Mass	109.13
Density	1.1143 (rough estimate)
Melting Point	168-169 °C (lit.)
Boling Point	204.59°C (rough estimate)
Flash Point	127.4°C
Solubility	DMSO, Methanol
Vapor Presure	0.00147mmHg at 25°C
Appearance	Crystalline powder
Color	Beige-brown
BRN	107937
pKa	10.38±0.10(Predicted)
Storage Condition	Inert atmosphere,Room Temperature
Refractive Index	1.5040 (estimate)
MDL	MFCD00082538
Use	It was used in the synthesis of pyrimidine.

Risk Codes	R22 - Harmful if swallowed R37/38 - Irritating to respiratory system and skin. R41 - Risk of serious damage to eyes R36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S36 - Wear suitable protective clothing.
WGK Germany	3
HS Code	29333990

NIST chemical information	Information provided by: webbook.nist.gov (external link)
Introduction	3-hydroxy-2-methylpyridine is a pharmaceutical intermediate, which can be prepared by one-step reaction of 2-acetylfuran and ammonia. 3-hydroxy-2-methylpyridine can be prepared with N-bromosuccinimide to prepare 2, 4-dibromo-3-hydroxy-6-methylpyridine, and then further react to prepare 2-bromo-5-hydroxy-6-methylpyridine.
Uses	3-hydroxy-2-methylpyridine is used for the preparation of substituted pyridine and pyrimidine derivatives and its use in the treatment of viral infections.
application	3-hydroxy-2-methylpyridine can be used as a chemical and pharmaceutical intermediate, which can be used in laboratory research and development and chemical and pharmaceutical synthesis.
preparation	0.03mol of 2-acetylfuran, 35mL of methanol, a certain amount of ammonium salt and 20.4g of 25% ammonia water are put into a 100 mL customized high-temperature digestion tank, stirred by magnetic force, and reacted at an oil bath temperature of 170 ℃ for 16h. After the reaction is completed, filtration, decolorizing the filtrate with activated carbon for 3 times, spinning off the solvent to obtain gray solid, 50% recrystallization and purification in ethanol water. 2-methyl -3-hydroxypyridine, melting point 167~171 ℃, molar yield 33.2%.
Biological activity	3-Hydroxy-2-methylpyridine It is isolated from theobromine extract and can be used for the synthesis of pyrimidine.

Last Update：2024-04-09 21:11:58

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CAS: 1121-25-1
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3-Pyridinol, 2-methyl-

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